99% Pharmaceutical Grade Peptides Powder Larazotide Acetate Powder for Treatment of Celiac Disease Raw Peptide Powder Larazotide Acetate Salt

• Customization: Available
• CAS No.: 2381089-83-2
• Formula: N/a
• EINECS: 200-001-8
• Type: Synthesis Material Intermediates
• Appearance: Powder
• Quality: Refined
• Colour: White
• Content: Standard
• Usage: Laboratory Reagents
• Source: Dry Powder
• Habit Appellation: Fine Chemicals
• Application: Scientific Research
• Specific Usage: Research Peptides
• Note: No Tfa Salt
• From: Authoried Regluar Workshop
• Raw Powder: 1g/Bottle
• Attention: Research Use Only
• Transport Package: Customized
• Specification: 1G/Bottle 2mg/5mg/10mg per vial
• Trademark: Hoconbio
• Origin: China
• Production Capacity: 5kgs Per Month

Product Description

Larazotide acetate (LA) is a single-chain peptide of eight amino acids that acts as a tight junction regulator to restore intestinal barrier function. LA is currently being studied in phase III clinical trials and is orally administered to adult patients with celiac disease as an adjunct therapeutic to enhance intestinal barrier function that has been disrupted by gliadin-induced immune reactivity. Mechanistically, LA is thought to act as a zonulin antagonist to reduce zonulin-induced increases in barrier permeability and has been associated with the redistribution and rearrangement of tight junction proteins and actin filaments to restore intestinal barrier function. More recently, LA has been linked to inhibition of myosin light chain kinase, which likely reduces tension on actin filaments, thereby facilitating tight junction closure. Small (rodent) and large (porcine) animal studies have been conducted that demonstrate the importance of LA as a tight junction regulatory peptide in conditions other than celiac disease, including collagen-induced arthritis in mice and intestinal ischemic injury in pigs.

Product Name	Larazotide Acetate
CAS NO.	881851-50-9
Other name	N/A
Appearance	White powder
Purity	98% HPLC
Application	Research peptides
Shelf Life	24 Months
Storage	Store at a temperature of 2-8 degrees, protected from light.